Which of the following sequences describes DNA packaging from least to most compacted?

The correct sequence for describing DNA packaging from least to most compacted is DNA double helix, nucleosome, 30 nm fiber, and radial loop domain.

To start with, the DNA double helix is the fundamental structural unit of DNA, comprising its two intertwined strands. This structure is the most basic and unorganized form of DNA.

Next, when DNA is wrapped around histone proteins, it forms nucleosomes, which look like "beads on a string." This organization is a crucial step in compacting DNA but is still not very compacted in comparison to other forms of chromatin.

As we move to the 30 nm fiber, this is a more compact structure formed by the nucleosomes further coiling and folding into a thicker fiber. The 30 nm fiber represents a significant level of organization and compaction of the DNA compared to the individual nucleosomes.

Lastly, the radial loop domain represents the highest level of compact organization. It involves the looping of 30 nm fibers and the attachment to a protein scaffold, which further condenses the DNA into a highly organized structure.

Thus, when considering the order of DNA packaging from least to most compacted, it logically follows the sequence presented: starting from the DNA double helix